The alleged abuse occurred between 2016 and January 2019, and was limited to two wards of the hospital that primarily serve patients with dementia, officials said.
“What has recently come to light is so profoundly hurtful, offensive, and heartbreaking for so many of us who care deeply about this hospital,” San Francisco Mayor London Breed said in a statement Friday morning.
"This behavior does not belong in our City or anywhere and can never be allowed to happen again. San Francisco is better than this, and significant changes will be made at Laguna Honda Hospital so it can fulfill its mission of caring for those most in need."
Laguna Honda, a public city-run facility, is a live-in hospital, nursing home and rehabilitation center serving nearly 800 patients.
In light of the allegations, DPH said it fired hospital CEO Mivic Hirose as well as its director of quality management and the six employees suspected of abuse. A department official declined to specify when the terminations occurred.
Margaret Rykowski, DPH's chief integrity officer, has since been appointed acting CEO and is leading the recovery process, officials said.
Breed, along with Board of Supervisors President Norman Yee and Dr. Grant Colfax, the city's recently appointed public health chief, addressed the scandal during a press conference on Friday at City Hall.
"We are here to report something difficult, disturbing and disappointing to the people of San Francisco," said Colfax. "This behavior is not something I will tolerate. As a caregiver, I am outraged and heartbroken that our patients were treated this way. I apologize to them and to their families."